Projekti i publikacije

Projekti i publikacije
 
Projekti:
1. „Uloga rezidentnih memorijskih CD8+ T-limfocita u mozgu nakon kongenitalne citomegalovirusne infekcije”. Odobreno od Federalnog ministarstva obrazovanja i nauke 2016. godine. Voditelj projekta: izv. prof. dr. Jurica Arapović.
2. „Istraživanje citomegalovirusne (CMV) infekcije središnjeg živčanog sustava na mišjem modelu“, 2015, znanstveno istraživanje je temeljeno na suradnji s Medicinskom fakultetu u Rijeci čiji je koordinator prof. dr. Stipan Jonjić i izv. prof. dr. sc. Jurica Arapović.
3. „Učestalost kongenitalnih citomegalovirusnih infekcija kod novorođenčadi na području Hercegovine”. Odobreno od Federalnog ministarstva obrazovanja i nauke 2010. godine. Voditelj projekta: izv. prof. dr. Jurica Arapović.
4.  „Opremanje uzgojnog vivarija za laboratorijske životinje na Medicinskom fakultetu Sveučilišta u Mostaru” u sklopu podrške javnim naučnim i visokoškolskim ustanovama (univerzitetima) od značaja za Federaciju. Odobreno od Federalnog ministarstva obrazovanja i nauke 2010. godine. Voditelj projekta: izv. prof. dr. Jurica Arapović.
5. „Sustav za krioprezervaciju tkivnih i staničnih uzoraka u tekućem dušiku” u sklopu podrške javnim naučnim i visokoškolskim ustanovama (univerzitetima) od značaja za Federaciju. Odobreno od Federalnog ministarstva obrazovanja i nauke 2012. godine na II. Javnom pozivu. Voditelj projekta: izv. prof. dr. Jurica Arapović.
6. „Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru“, Ministarstvo znanosti obrazovanja i športa Republike Hrvatske, Voditelj projekta: prof. dr. Stipan Jonjić. Razdoblje 2004-2008.
7. „Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru“, Ministarstvo znanosti obrazovanja i športa Republike Hrvatske, Voditelj projekta: prof. dr. Stipan Jonjić. Razdoblje 2008-2016.
8. „Uloge temeljnih imunoloških mehanizama u nadzoru herpesvirusnih infekcija i razvoj novih virusnih cjepiva i vektora za cjepiva“, Voditelj projekta: prof. dr. Stipan Jonjić.
 
Publikacije:
1. Skocibusic S, Martinac M, Arapovic J, Grgic S, Nikolic J, Hasanagic D, Bevanda M, Ravlija J. HBV  and HCV serological monitoring among injection drugs users in opiate substitution treatment in Bosnia and Herzegovina. J Infect Dev Ctries. 2016 Sep 30;10(9):968-972. doi: 10.3855/jidc.7445.
2. Arapović M, Brizić I, Popović B, Jurković S, Jordan S, Krmpotić A, Arapović J, Jonjić S. Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection. Front Immunol. 2016 Apr 6;7:133. doi:10.3389/fimmu.2016.00133.
3. Grgic S, Skocibusic S, Celjuska-Tosev E, Nikolic J, Arapovic J, Kuzman I. Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11. J Infect Dev Ctries. 2016 Feb 28;10(2):155-62. doi: 10.3855/jidc.6040.
4. Rajič B, Arapović J, Raguž K, Bošković M, Babić SM, Maslać S. Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report. J Infect Dev Ctries. 2015 Jul 30;9(7):788-91. doi:10.3855/jidc.4851.
5. Arapović J, Arapović M, Golemac M, Traven L, Tomac J, Rumora D, Ražić E, Krmpotić A, Jonjić S. The specific NK cell response in concert with perforin prevents CD8(+) T cell-mediated immunopathology after mouse cytomegalovirus infection. Med Microbiol Immunol. 2015 Jun;204(3):335-44. doi: 10.1007/s00430-015-0409-y.
6. Arapović J, Skočibusić S, Jelavić B, Ivanković HB, Jurić M, Mamić D, Grgić S, Lesko J, Leventić M, Soldo I, Ravlija J, Nikolić J. Two cases of human cutaneous anthrax in Bosnia and Herzegovina, September 2014. Euro Surveill. 2015 Feb19;20(7):2-4.
7. Arapovic J, Skocibusic S, Grgic S, Nikolic J. The first evidence of lyme neuroborreliosis in southern bosnia and herzegovina. Case Rep Infect Dis. 2014;2014:231969. doi: 10.1155/2014/231969.
8. Trsan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapovic M, Babic M, Tomic A, Golemac M, Brinkmann MM, Jäger W, Oxenius A, Polic B, Krmpotic A, Messerle M, Jonjic S. Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16550-5. doi: 10.1073/pnas.1310215110.
9. Wagner FM, Brizic I, Prager A, Trsan T, Arapovic M, Lemmermann NA, Podlech J, Reddehase MJ, Lemnitzer F, Bosse JB, Gimpfl M, Marcinowski L, MacDonald M, Adler H, Koszinowski UH, Adler B. The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex. PLoS Pathog. 2013;9(7):e1003493. doi: 10.1371/journal.ppat.1003493.
10. Jordan S, Ruzsics Z, Mitrović M, Baranek T, Arapović J, Krmpotić A, Vivier E, Dalod M, Jonjić S, Dölken L, Koszinowski UH. Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection. Cell Host Microbe. 2013 May 15;13(5):535-45. doi: 10.1016/j.chom.2013.04.007.
11. Mitrović M, Arapović J, Traven L, Krmpotić A, Jonjić S. Innate immunity regulates adaptive immune response: lessons learned from studying the interplay between NK and CD8+ T cells during MCMV infection. Med Microbiol Immunol. 2012 Nov;201(4):487-95. doi: 10.1007/s00430-012-0263-0. Review.
12. Mitrović M, Arapović J, Jordan S, Fodil-Cornu N, Ebert S, Vidal SM, Krmpotić A, Reddehase MJ, Jonjić S. The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8(+) T-cell response. J Virol. 2012 Feb;86(4):2165-75. doi: 10.1128/JVI.06042-11.
13. Jordan S, Krause J, Prager A, Mitrovic M, Jonjic S, Koszinowski UH, Adler B. Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2. J Virol. 2011 Oct;85(19):10346-53. doi: 10.1128/JVI.00545-11.
14. Jovanovic I, Radosavljevic G, Mitrovic M, Juranic VL, McKenzie AN, Arsenijevic N, Jonjic S, Lukic ML. ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma. Eur J Immunol. 2011 Jul;41(7):1902-12. doi: 10.1002/eji.201141417.
15. Radosavljevic G, Jovanovic I, Majstorovic I, Mitrovic M, Lisnic VJ, Arsenijevic N, Jonjic S, Lukic ML. Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. Clin Exp Metastasis. 2011 Jun;28(5):451-62. doi: 10.1007/s10585-011-9383-y.
16. Slavuljica I, Busche A, Babić M, Mitrović M, Gašparović I, Cekinović D, Markova Car E, Pernjak Pugel E, Ciković A, Lisnić VJ, Britt WJ, Koszinowski U, Messerle M, Krmpotić A, Jonjić S. Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties. J Clin Invest. 2010 Dec;120(12):4532-45. doi: 10.1172/JCI43961.
17. Babić M, Pyzik M, Zafirova B, Mitrović M, Butorac V, Lanier LL, Krmpotić A, Vidal SM, Jonjić S. Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo. J Exp Med. 2010 Nov 22;207(12):2663-73. doi: 10.1084/jem.20100921.
18. Mohr CA, Arapovic J, Mühlbach H, Panzer M, Weyn A, Dölken L, Krmpotic A, Voehringer D, Ruzsics Z, Koszinowski U, Sacher T. A spread-deficient cytomegalovirus for assessment of first-target cells in vaccination. J Virol. 2010 Aug;84(15):7730-42. doi: 10.1128/JVI.02696-09.
19. Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17858-63. doi: 10.1073/pnas.0903474106.
20. Arapovic J, Lenac T, Antulov R, Polic B, Ruzsics Z, Carayannopoulos LN, Koszinowski UH, Krmpotic A, Jonjic S. Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus. J Virol. 2009 Aug;83(16):8198-207. doi:10.1128/JVI.02549-08.
21. Arapović J, Lenac Rovis T, Reddy AB, Krmpotić A, Jonjić S. Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60. Mol Immunol. 2009 Nov;47(1):114-22. doi:10.1016/j.molimm.2009.02.010..
22. Jonjic S, Krmpotic A, Arapovic J, Koszinowski UH. Dissection of the antiviral NK cell response by MCMV mutants. Methods Mol Biol. 2008;415:127-49. doi: 10.1007/978-1-59745-570-1_8.
23. Lenac T, Arapović J, Traven L, Krmpotić A, Jonjić S. Murine cytomegalovirus regulation of NKG2D ligands. Med Microbiol Immunol. 2008 Jun;197(2):159-66. doi: 10.1007/s00430-008-0080-7.
24. Lenac T, Budt M, Arapovic J, Hasan M, Zimmermann A, Simic H, Krmpotic A, Messerle M, Ruzsics Z, Koszinowski UH, Hengel H, Jonjic S. The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. J Exp Med. 2006 Aug 7;203(8):1843-50.